Published to Tetrahedron

Check out our latest paper on radical NHC catalysis in Tetrahedron: Radical N-heterocyclic carbene catalysis for β-ketocarbonyl synthesis. N-Heterocyclic carbene-catalyzed radical cross-coupling between aldehydes and α-bromoesters or α-bromoamides is described. β-Ketocarbonyl compounds having a quaternary carbon center at the α-position can be synthesized under mild reaction conditions. Both aromatic and aliphatic aldehydes are suitable acyl donors by employing proper NHC catalyst precursors.